Intrauterine growth restriction (IUGR) is defined as a condition associated to pathological situation in which fetal alteration and genetic capabilities of growth are combined (Platz, 2008). After fetus is affected, it uses hepatic reservoir of energy in order to keep the balance and as a consequence, hepatic volume decrease (Ebbing, 2009). Three dimensional ultrasound has been use to better understand anatomy and pathophysiology of different organs (Pretorius, 1998). Power Doppler has been used to evaluate the vascular tree and the quantification of total blood flow in the fetal liver (Chang, 2003). The use of vascular indices such as vascularization index (VI), flow index (FI) and vascularization flow index (VFI) in fetal liver as a quantitative method of evaluation of vascular anatomy and pathophysiology has been introduced. The aim of this study is to report possible changes in three dimensional power Doppler indices when the evaluation of the fetal liver in IUGR is been performed. We performed a prospective observational study of all consecutive cases with the diagnoses of IUGR and we compared those findings with a control group. Fetal evaluation was performed using Accuvix V10 ultrasonographic equipment (Medison, Seoul-Korea). Hepatic volume calculation was obtained using Virtual Organ Computer-Aided Analysis (VOCAL™, 3DXI, Medison Sonoview Pro, Seoul, Korea) with 30 degrees swept. VI, FI and VFI were obtained in all cases. After 10 fetuses were evaluated, we found that VI, FI and VFI were higher in the IUGR group when compared with normal fetuses. The analysis of the hepatic vascularization and the vascularization Indices by three-dimensional power Doppler could be useful to make an evaluation of the hepatic vascularization in fetuses with IUGR; however, further studies are required to confirm the results and the potential uses of this instrument in the assessment of this pathology.