Cytomegalovirus (CMV) is one of the most common cause of intrauterine infection associated with prenatal and postnatal consequences. Prenatal ultrasound findings placentomegaly, intrauterine growth retardation, amniotic fluid changes, hepatosplenomegaly, and bowel calcifications, ventriculomegaly, brain calcifications and hydrops. We report a case a CMV prenatal infection with fetal findings that went to fetal therapy with hyper immunoglobulin presented good response to treatment and regression of the main fetal findings. A 24 years old G2P1 with 25, 5 weeks old pregnancy was evaluated in the fetal therapy unit. Fetal biometry was consistent with 25, 4 wo, periventricular calcificacions, ventriculomegaly, at the fetus central nervous system was described. Ascitis, hyperechogenic bowel, visceromegaly, placentomegaly and polihidramnios. CMV IgG was positive, IgM was negative but IgG avidity was low. Amniocentesis for PCR Parvovirus B19 and toxoplasma were negative and PCR CMV was positive. Fetal kariotype was normal. We began treatment for congenital CMV with Hyperimmune globulin total dose was (150 mg/kg). Patient was monitored closely during and after each rate change. After the first dose, plasma CMV viral load was less than 375 copies/ml. Fetal ultrasound follow up showed no ventriculomegaly, fetal regress of the hydrops and improved of the placentomegaly. She underwent second treatment after 2 weeks period placental thickness improved from 6 cm to 4 cm. At GA of 40–1/7 she went on to deliver a viable female infant with APGARs of 8 at 9. Weight 7 pounds 13 ounces. The infant was transferred to NICU. Neonatal deafness in right ear was diagnosed. No other neurological deficits were noted in the pediatric follow up. The prenatal therapy with hyper immunoglobulin should be considered as an option after the prenatal diagnosis of congenital CMV. Further studies will be considered necessary in order to define the standard of care in CMV prenatal therapy.