In the context of important political, economic and social changes, telework becomes a phenomenon that combines many of the key factors for change: flexibility, information and communication technologies (ICT), and new ways of interaction. In order to analyze the relationship between subjectivity and telework, this article presents theoretical and empirical studies of several authors regarding subjects, subjectivity and (tele)work. The article examines different approaches, ranging from those which consider telework a degradation of traditional work with regard to social and personal functions, with perverse effects for people, to those which telework a challenge, or an opportunity, to create new dynamics, meanings, spaces, and, of course, ontological projects.