Malpelo Island forms the insular ecoregion of the Colombian Pacific, and is composed by a mosaic of terrestrial ecosystems, and unique coastal and shallow subtidal systems. Considering its insular nature, the oceanographic features of this locality are expected to be related with the physical and chemical dynamics of the Eastern Tropical Pacific (ETP) and be modulated by the regional dynamic of the Colombian Pacific Oceanic Basin (COPC in Spanish). In this work, in situ data was used to describe the thermohaline conditions in the water column in Malpelo Island and identify key water mass during the two contrasting hydro-meteorological periods of the COPC. Furthermore, we analyzed the thermal and haline variability in the COPC and defined the surface geostrophic flow from in situ oceanographic data during the same time in order to evaluate its effect on the oceanographic conditions in the pelagic environment off Malpelo Island.