Antecedentes: la tosferina es una enfermedad respiratoria aguda de una alta transmisibilidad sobre todo en ambitos intrafamiliares o intradomiciliarios. En febrero de 2008, fue informado un brote de tosferina con casos confirmados por nexo epidemiologico, algunos de los cuales no presentaban vacunacion certificada y se carecia de claridad sobre sus caracteristicas clinico-epidemiologicas para determinar el comportamiento de la enfermedad. Materiales y Metodos: estudio descriptivo de corte transversal. Se establecio la definicion de caso confirmado por laboratorio y confirmado por nexo epidemiologico; ademas, se realizo busqueda activa comunitaria e institucional, barrido de vacunacion y monitoreo rapido de coberturas de vacunacion y establecimiento de medidas quimio-profilacticas. Resultados: se confirmo un caso por laboratorio y 4 por nexo epidemiologico. Periodo de incubacion =16,2 dias; tasa de ataque total para las dos viviendas implicadas 33% (5/15). De las 52 casas visitadas, 42 fueron efectivas, no se presento ausentismo de ninos en las instituciones visitadas y se evidencio 100% de cobertura para DPT. De 24170 registros revisados, 3227 tenian diagnostico compatible, 17 fueron clasificados como probables de tosferina, 7 investigados. Conclusiones: existen dificultades en la captacion de casos de tosferina, subnotificacion al SIVIGILA y dificultades en el diagnostico por laboratorio para el aislamiento de la bacteria; se hace necesario reforzar la vigilancia del evento por parte de todas instituciones de salud y fortalecer la capacidad del laboratorio de salud publica. Abstract Antecedents: whooping cough is an acute respiratory disease that is highly contagious, particularly within confined areas such as family units or shared domestic spaces. In February 2008 an outbreak of whooping cough was reported and cases of the respiratory illness corroborated by epidemiological analysis. Of these cases a certain number had not received a certified vaccine, in addition to which they lacked the sufficient clinical and epidemiological detail to determine the nature of the illness. Methods: a field study of a cross section of the population was undertaken. The nature of the case was confirmed in the laboratory and by epidemiological analysis. At the same time an eradication plan was implemented at an institutional and national level, a policy of mass vaccination was instigated and a process for onitoring the coverage of the vaccinations across the population was rapidly introduced. Chemical prophylactic antidotes were also introduced. Results: one case was confirmed by the laboratory and 4 by epidemiological analysis. The incubation period was established at =16.2 days; the total households affected was 33% (5/15). Of the 52 houses visited 42 were declared safe, there was no sign of child absenteeism in the institutions visited and 100% coverage was recorded across the state. Of the 24170 cases that were registered and attended to, 3227 had compatible diagnoses, 17 were marked as likely cases of whooping cough and 7 were followed up in investigation. Conclusions: there are difficulties in detecting cases of whooping cough and not enough incidents are reported to SIVIGILA, laboratory diagnosis, which could isolate the bacteria is problematic. It is indispensable that all health institutions raise awareness of the condition and that the resources of the public health laboratories be improved. Keywords: whooping cough, family unit, shared domestic spaces, epidemiological analysis, chemical prophylactics.