Vegetation change under two climate change scenarios in different periods of the 21 st Century are modeled for Colombia. Vegetation for the years 1970 to 2000 was reproduced using the Holdridge model with climate data with a spatial resolution of 900 meters. The vegetation types that occupied the most territory were sub-humid tropical forest, tropical dry forest and Andean wet forest. These results were validated by comparing with the Colombian ecosystem map (SINA, 2007), which confirmed a high degree of similarity between the modeled spatial vegetation patterns and modern ecosystem distributions. Future vegetation maps were simulated using data generated by a regional climate model under two scenarios (A2 and B2; IPCC, 2007) for the periods 2011-2040 and 2070-2100. Based on our predictions high altitude vegetation will convert to that of lower altitudes and drier provinces with the most dramatic change occurring in the A2 scenario from 2070-2100. The most affected areas are the paramo and other high Andean vegetation types, which in the timeframe of the explored scenarios will disappear by the middle of the 21 st Century.