The intention of this study was to study the quality of life and the conduct of disease in people with diabetes and to observe if relation among them exists. For it is was applied to questionnaire SF-36 and the IBQ to 74 patients with ages between the 45 and 65 years diagnosed with diabetes mellitus type II. Important deterioration in the quality of life of these patients was demonstrated, mainly in those components related to the physical health. The disease conduct scored in the average rank in all its dimensions, coming near at a high level the general hipocondriasis. Were inverse correlations between the physical function, with psychological perception versus somatic of the disease. The mental health also correlated of negative form with affective distortion, negation of the problems and irritability. The existing relation between the evaluated dimensions allows an approach to the exposition of patterns of answer to the disease that result in the quality of life of the patient with diabetes.