Chemosensitive LC neurons from bullfrogs increase their firing rate and have altered action potential (AP) waveforms upon cooling from 20°C to 10°C (Santin et al. , Amer. J. Physiol. Doi:10.1152/ajpregu.00348.2013). We developed a computational model to study this unusual neuronal response to cold temperature. Using MatLab, we have a 4 dimensional model based on a Hodgkin‐Huxley formulation that includes a voltage‐gated Na channel, a delayed‐rectifying K (K dr ) channel and a leak K channel. The model generates a firing rate of ~12 Hz and AP waveforms that are similar to those of bullfrog LC neurons at 20°C. For instance, values (neuron:model) for AP height (60 mV:51 mV), maximum rate of depolarization (36 mV/ms:40 mV/ms), maximum rate of repolarization (‐27 mV/ms:‐23 mV/ms), the AP width (2.1 ms:2.6 ms) and after hyperpolarization (AHP) (‐60 mV:‐66 mV) are similar comparing the model to the actual neuron. Colder temperature (10°C) decreases neuronal maximum rates of depolarization and repolarization, increases the AP width, and decreases the AHP. Changing, in a depolarizing direction, the voltage at which the time constant of inactivation for K dr channels reaches a maximum and increasing the time constant for Na channel activation in the model results in similar changes in AP waveform parameters. However, the model changes result in decreased firing rate (~6 Hz) while temperature changes in neurons result in increased firing rate. This suggests that another channel is involved in the temperature effects on firing rate. In line with this, we found a hyperpolarization‐activated current (I H ) in LC neurons that will be added in our model to determine if altering the parameters of the I H current contributes to cold temperature‐induced increased firing rate in bullfrog LC neurons. We ultimately plan to use both the model and electrophysiology studies to gain insights into the neuronal basis for chemosensitivity and cold temperature responses in chemosensitive LC neurons from bullfrog. Grant Funding Source : Supported by Admin. Dept. of Sci., Technol. & Innov. of Col (COLCIENCIAS) and NSF Grant IOS‐1257338.