Factores no tradicionales influyentes en la calidad de vida de los pacientes de hemodiálisis 18 Results: A decrease in QOL in the physical components (PCS) Mental components (MCS) regarding the general population.A significant correlation between low PCS and diabetes mellitus (-16 p=0.008 95% CI 2.49) was found.Low MCS showed relation with PTH (p=0.04695% CI 0.000-0.014),Karnofsky index (p=0.03495% CI 0.244 to 5.984) and Beck depression test (p=0.00095% CI -13.606 to 6.253). Conclusions:The QOL of hemodialysis patients is affected with more impact on PCS, there is significant relationship between MCS with functional status and depression.To improve QOL in hemodialysis patients, non traditionally-measured variables should be measured and monitored and the therapeutic focus should be optimized addressed to physical rehabilitation, nutritional, functional and psychological state.