The aim of the present study was to develop and validate an intervention program to the empowerment of resilience for patients with rheumatoid arthritis. We used a quasi-experimental non-randomized pre-post two-group design; the experimental group was also assessed at follow-up. The total sample consisted of 76 patients (93% women). The results of both Study 1 (n = 26; pilot study) and Study 2 (n = 50) showed a positive effect of treatment on some of the outcome variables, including resilience, self-transcendence, mood states, quality of life, illness perception, and social support. Thus, the intervention program can enhance resilience and significantly improve psychosocial variables associated with rheumatoid arthritis.