Hyperglycemia without previous history of diabetes mellitus (DM) is observed in a high percentage of patients in intensive care units (ICU). To determine the behavior of glycemia in nondiabetic patients with hyperglycemia by administering two micronutrients. A clinical trial was conducted in 32 patients, 16 in the intervention group and 16 in the control group. To the intervention group was given, since the admission, the micronutrients vitamin D3 in doses of 1.000 international units (IU) and calcium in doses 1.000 mg every 24 hours, for a period of 72 hours. No significant differences were observed in blood glucose income between the intervention and control groups (152,6 and 153,3 mg / dl, respectively p = 0,922), but after 72 hours the behavior of the glycemia decreased significantly in the intervention group compared to the control group (98,41 and 141,6 mg / dl respectively p 100 mg/ dl), showing that 2,29 patients should be treated to decrease an undesirable event (NNT). The use of the analyzed micronutrients in critically ill patients with no previous diagnosis of diabetes requires more research that addresses te limitations posed here. Due to the limited literature found about similar studies, this investigation would provide another alternative for reducing hyperglycemia in these patients.