Objective The aim of this study was to determine the association between excessive weight and physical inactivity among college students. Material and methods An analytical cross sectional study was carried out in 2013 among college students from a private university of Bucaramanga, Colombia. Students (n=306) 18 to 25 years old were included using simple random sampling. We used the International Physical Activity Questionnaire (IPAQ). We evaluated height, weight, body mass index (BMI), total fat percentage, and waist and hip circumferences. The association between excessive weight and physical inactivity was estimated using regression logistic models that allows estimate row and adjusted Odds Ratios (OR). Results Taking into account the total fat percentage, 12.09% of the students were in risk of becoming obese and 10.13% were already obese. 50.56% of the students practiced very little weekly physical activity. A statistically significant association was found between excessive weight and sedentary behavior, according to the total fat method (adjusted OR: 1.11, CI 95%: 1.01-1.23). Conclusions Our study observed an association between physical inactivity and excessive weight. Physical inactivity is an important lifestyle factor related to chronic diseases. Acknowledgment COLCIENCIAS, REF. Agreement N°. 734, 2013.