The Staphylococcus spp gender constitutes an important group of pathogens in the human being and it yields various diseases, among them the infective endocarditis. The presence of species of Staphylococcus spp like residents of the oral flora are controversial, also there are few studies in the literature about the distribution of these microorganisms in the mouth. Aim: To know the sensitivity of Staphylococcus spp to the amoxicillin and the clindamycin isolated in oral cavity of patients with high risk of Infective endocarditis.Materials and Methods: Forty six patients that attended to the service of Stomatology and Cardiology of HOCEN during the month of August 2010 were included, which meeting the criteria of patients with high risk of Infective endocarditis. The patients with you cognitive problems and with allergy to the material for the collecting of the sample were excluded of this study. The salivary sample was taken and it was grown in sheep blood agar, Staphylococcus spp was identified of the rest of microorganisms. It was carried out an antibiogram to establish the sensitivity, confirmed by BD MicroScan. Results: Out of the 46 patients, 28.2% was positive for Staphylococcus spp. From those 61.5 % were positive for Staphylococcus aureus, 30.7% for S. epidermidis and 7.6% for S. hominis. Sixty nine per cent of the Staphylococcus spp was sensitive to the clindamycin, 23% sensitive to the amoxicillin and 76.9% resistant to penicillin. Conclusion: The 28.2% of the patients presented a prevalence of Staphylococcus spp from which was found resistance to amoxicillin 76,9% of the cases and to clindamycin in 30,8%, which makes necessary to assess the need to use an antibiotic prophylaxis with a wider covering to the microorganisms of the oral cavity.