RESUMEN Introduccion: Las deficiencias hormonales pueden afectar el complejo craneofacial durante el crecimiento y desarrollo esqueletico. Objetivo: Determinar si existia evidencia cientifica acerca de la asociacion entre el tratamiento hormonal y el crecimiento craneofacial en personas con deficiencia hormonal entre los 10 y 18 anos de edad evaluados cefalometricamente. Materiales y metodo: Revision sistematica de la literatura en Pubmed, Google academico, Lilacs, Embase, ScienceDirect, sin limite de ano de publicacion. Se incluyeron ensayos clinicos, estudios de casos y controles, cohorte, revisiones sistematicas y meta-analisis. Se hizo lectura ciega e independiente por parte de 2 investigadores, de los resumenes y los articulos completos. Resultados: De 1085 articulos encontrados se excluyeron 1074 por no cumplir criterios de inclusion. Luego de la lectura completa se excluyeron 5 por ser estudios transversales y uno porque no se tuvo acceso a el, quedando un total de 6 articulos incluidos. Estas investigaciones reportaron que los pacientes tratados con terapias de sustitucion hormonal presentaron cambios favorables en las estructuras craneofaciales, especialmente la longitud total mandibular, longitud de la rama y cuerpo mandibular; tambien presentaron mejoria del perfil facial, relaciones intermaxilares y estructuras oseas corporales. Conclusiones: A pesar de la heterogeneidad de los estudios,se encontro queel tratamiento temprano de sustitucion hormonal, independientemente de la dosis y siempre y cuando sea a largo plazo, acelera el desarrollo de estructuras craneofaciales, principalmente de la mandibula, hasta lograr los patrones esqueleticos establecidos geneticamente. Se requieren estudios que evaluen el efecto de la terapia de sustitucion hormonal en pacientes sin compromisos sistemicos adicionales. Palabras claves: Hormonas, crecimiento y desarrollo, anomalias craneofaciales, cefalometria, mandibula, deficiencia. SUMMARY Background: Hormone deficiency could affect craniofacial complex during esqueletal growth and development. Objective: Determine whether there is scientific evidence of the association between hormonal treatment and craniofacial growth measured by cephalometry films, in subjects of 10 to 18 years with hormonal treatment. Materials and Methods: A systematic review. For the articles published in PubMed, Google Scholar, Lilacs, Embase and Science Direct databases, without restriction of publication year was performed. Clinical trials, case control studies, cohort, systematic reviews and meta analysis studies were included. Reading of the abstracts and the complete articles were made by two researchers. Results: Among 1085 articles found, 1074 were excluded because did not meet the inclusion criteria. After complete reading of the articles, five were excluded because they were cross-sectional studies and one was not recovered in the full text. In total, 6 articles were included. These studies report that patients who were treated with hormone substitution therapy showed favorable changes in their craniofacial structures, especially in mandibular total length, ramus length and mandibular body length. These positive changes led to an improvement in profile, inter-maxillary relations, and other osseous body structures. Conclusions: Despite the heterogeneity of the studies it was found that early replacement with hormone treatment, regardless of the dose and long-term treatment, accelerates the development of craniofacial structures, mainly the mandible, to reach the skeletal patterns genetically established. Studies are required to evaluate replace hormone treatment in patients without additional systemic compromises. Keywords: Hormones, growth and development, craniofacial disorders, cephalometry, mandible, deficiency.