INTRODUCTION: Cuba has a well–developed and high quality primary care system. Taking it into consideration is very important to develop a standardized program and an evidence–base guideline to improve (the health) medical care in women with Epilepsy (WWE). OBJECTIVE: To carry out a systematic analytic review of the evidence related to the management issues for WWE and to suggest an evidence–based guideline to standardize their care in Cuba. METHODS: A committee assembled by neurologists, psychiatrists, neuropediatricians and general practitioners of the ILAE Cuban Chapter and National Neurology and Neurosurgery Society, reassessed the evidence related to the care of WWE. To answer the questions with respect to attention of WWE, the panel searched information in PubMed, Cochrane, MEDLINE, BIREME and Scielo data bases. The articles were rated according to the European Federation of Neurological Societies classification of therapeutic evidence scheme. We analyzed 2456 relevant articles, four evidence based guidelines and different national investigations presented in the national conference on epilepsy which takes place in Havana each year. DEVELOPMENT: We provided the evidence–based answers to each question and gave the corresponding recommendation regarding treatment and follow–up of WWE in primary, secondary and tertiary attention levels. The recommendations included topics concerning to preconception counseling, pregnancy, delivery, postpartum and menopause periods. CONCLUSIONS: This guideline constitutes a proposal to the management issues for WWE. It has been elaborated after critical review of evidence–based literature. The authors hope it improve the quality of medical assistance in this group of patients in daily clinical practice.