Introduccion: la extravasacion del plasma es la manifestacion mas severa de la enfermedadproducida por los virus del dengue y que con mayor frecuencia conduce al estado de choque. Secaracteriza por derrames serosos a nivel de diversas cavidades y aumento del hematocrito. Se realizoel presente estudio con el objetivo de determinar los factores sociodemograficos, clinicos y de laboratorioque mas se asocian a la presencia de extravasacion plasmatica en los pacientes con dengue. Materiales y metodos : estudio observacional analiticotransversal, analizado bajo la metodologia de casosy controles, a partir de registros clinicos de pacientes condengue. Se utilizaron prueba Chi cuadrado de Pearson,prueba exacta de Fisher, prueba no parametrica U deMann-Whitney y un modelo de regresion logistica multivariadode factores asociados. Fueron calculados los OddsRatio con su intervalo de confianza al 95 %. Se consideroun nivel de significancia de 5 %. Resultados: fueron analizados un total de 350 registros,de los cuales 128 presentaron signos de extravasacionplasmatica (36,6 %). Despues de ajustar por factoresde confusion se observo que las variables que masse asocian a presencia de extravasacion plasmatica enlos pacientes con dengue fueron el dolor abdominal, laleucopenia y las melenas Conclusion: estos hallazgos clinicos y de laboratoriodeben ser priorizados en su vigilancia en la atencion alpaciente con dengue, para identificar los casos con mayorprobabilidad de extravasacion plasmatica para sumanejo oportuno y adecuado. PALABRAS CLAVE Dengue, Signos y sintomas, Extravasacion plasmatica, Factores de riesgo ABSTRACT Introduction: Plasma leakage is the most severecomplication caused by dengue virus infectionand is also the mechanism that frequentlyleads to dengue shock syndrome. Plasma leakageis characterized by ascites, pleural and pericardialeffusion and increased hematocrit level.The present study was conducted to identifysocio-demographic, clinical and laboratory factors that more are associated to the presence ofplasma leakage in dengue infected patients. Materials and methods: A cross sectionalanalytic study was performed on clinical recordsfrom dengue infected patients using the casecontrolmethodology. Pearson’s chi-square testor Fisher´s exact test, Mann-Whitney’s non-parametricU test and a multivariate logistic regressionmodel of associated factors were used toevaluate the data. Odd Ratios with 95 % confidenceintervals were calculated and significancelevel of 5 % was considered. Results: A total of 350 clinical records wereanalyzed, 128 cases (36.6 %) presented signs ofplasma leakage. After adjustments by confoundingfactors, we observed that abdominal pain,leukopenia and melena were the variables thatexplain the presence of plasma leakage in dengueinfected patients. Conclusion: During the follow-up of dengue infectedpatients priority should be given to thesurvey of these clinical and laboratory findingsin order to identify the cases with higher probabilitiesof developing plasma leakage, allowingachieving more timely and appropriate management. KEY WORDS Dengue virus, Signs and symptoms, Plasma leakage, Risk factors