The mobility plan and the road infrastructure works implemented, together with the Bus Rapid Transit (BRT) connected bus system in its first two phases, generated optimistic expectations about the reduction of lethal crashes in the city. This research studies the relationship between investments in transportation infrastructure in the city and the distribution of traffic fatalities. Although it is not strictly speaking an impact assessment, the approach we propose performs geostatistical contrasts between intervened and non-intervened areas, using a geographically weighted model that attempts to model the spatial variability of the factors associated with the intra-urban road traffic crash rate, controlling for infrastructure interventions and some proxy indicators of urban structure. The findings reveal that fatalities decreased in areas both with and without intervention. Despite the expectation of reducing fatal injuries, the differential effects of the interventions were relatively small. The risk of road traffic crashes was even increased in critical points of the city with recurrent lethal crashes. The effects of road interventions on fatal road traffic crashes in Cali did not correspond to the high social and economic costs involved in the BRT system and the work plan.