Clinical features, risk factors and susceptibility profile of mycobacterial infections documented by culture in a university hospital of high complexity in Medellin (Colombia)Introduction: Tuberculosis (TB) remains an entity of high prevalence and mortality worldwide.The rising drug resistance is a public health problem.Besides, non-tuberculosis mycobacterial (NTM) infections are described with increasing frequency in areas of high prevalence of TB.Objectives: To determine epidemiological, clinical and microbiological characteristics of mycobacterial infections documented by culture.Materials and Methods: An observational, descriptive study in hospitalized patients.Results: M. tuberculosis complex was identified in 90,9% of 187 patients; 9,1% had NTM, 64% were male and the mean age was 40 years (range 1-88 years).The main co-morbidities were HIV / AIDS (23.5%), use of corticosteroids (13.3%) and chronic kidney disease (9.6%).Clinical forms were pulmonary (56.6%), extra-pulmonary (23.9%) and disseminated (19.2The most common extra-pulmonary compromise was nodal (7.4%) and gastrointestinal (7%).10.6% of M. tuberculosis were multidrugresistant (MDR) and 2.12% had extended drug resistance (XDR).Mycobacterium avium and M. abscessus were the most frequent NTM.Overall mortality was 10%.Conclusions: In our study immune suppression is the main risk factor for extrapulmonary and disseminated disease.Resistance, MDR and XDR is higher in inpatients with TB.MNT infections are not uncommon in our country.