Currently, the trend of micro-grids and small-scale renewable generation systems implementation in urban environments requires to have historical and detailed information about the energy potential resource in site. In Colombia, this information is limited and do not favor the design of these applications; for this reason, must be made detailed studies of the energy potential in their cities. In this paper is presented the wind and solar energy resource assessment for the city of Bucaramanga, based on the monitoring on four strategic points during the years 2010, 2011 and 2012. According to the analysis, is evidenced a significant solar resource throughout the year ascending on average to 1 734 kWh/m2, equivalent to 4.8 kWh/m2/day. Also, from a wind statistical study based on the Weibull probability distribution and Wind Power Density (WPD) was established the wind potential as Class 1 according to the scale of the Department of Energy of the United States (DOE), since the average speed is near 1.4 m/s. Due this, it is technically unfeasible the using of micro-turbines in the city, even so their potential for natural ventilation of building was analyzed. Finally, is presented a methodology to analyze solar harvesting by sectors in the city, according to the solar motion and shadowing caused by existing structures.