Due to economical reasons and the need for environmental conservatism, there has been an increasing shift towards the use of reclaimed asphalt pavement (RAP) materials in the pavement construction industry. This is a relatively new concept in Colombia with scarce local documented literature, particularly on the mechanical properties of the hot mix asphalt (HMA) mixtures modified by addition of RAP and the corresponding mixture design procedures. This research focused on evaluating the effects of partial- and total-replacements of aggregates by RAP on the mechanical response of dense-graded HMA mixtures. Corresponding results suggest that the highest indirect tensile strength and resilient modulus values in both dry- and wet-condition were obtained for the HMA mixtures produced with 100% replacement of granular material by RAP.